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DUSP2 Suppresses the Chromatin Remodeling BAF Complex to Orchestrate CD8+ T Cell Effector Programming [RNA-seq]

GSE310048 Homo sapiens (human) RNA-seq (gene expression) 8 samples Submitted 2026/07/31 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 8 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
8 samples: 2 × Peripheral CD8+ T cells, siDUSP2 transfected, healthy dono vs 2 × Peripheral CD8+ T cells, siControl transfected, healthy dono vs 2 × Peripheral CD8+ T cells, siDUSP2 transfected, anti-CD3/CD28 activated, 24-hours, healthy dono vs 2 × Peripheral CD8+ T cells, siControl transfected, anti-CD3/CD28 activated, 24-hours, healthy donoGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodelingJournal of immunology (Baltimore, Md. : 1950) · 2026
Summary (written by the submitters)
Effector gene expression in CD8⁺ T cells is tightly controlled at epigenetic and transcriptional levels; however, crucial regulatory signals remain incompletely understood. In this study, we identify Dual Specificity Phosphatase 2 (DUSP2) as a key epigenetic modulator of effector CD8⁺ T cell state, by elucidating inhibition of BAF-mediated chromatin opening by DUSP2.
Read the full summary ↓
Induced downregulation of DUSP2 in human CD8+ T cells enhanced cytotoxicity and effector phenotypes by increasing chromatin accessibility through upregulation of BAF subunits, such as SMARCA4, and permitting binding of ETS1 to BAF subunit gene loci and those essential for effector programs. Conversely, during chronic activation, DUSP2 knockout in murine CD8+ T cells predisposed terminally differentiated effector cells to exhaustion. These findings uncover a previously unrecognized role of DUSP2 in the management of the chromatin landscape in CD8+ T cells and the epigenetic fine-tuning of their functionality, highlighting DUSP2 as a promising therapeutic target for T cell-based immunotherapy.
Published in
CD8+ T-cell effector programming is epigenetically regulated by DUSP2 through BAF complex-driven chromatin remodeling
Dellacecca ER, Hirdler JB, Barham W et al. · Journal of immunology (Baltimore, Md. : 1950) 2026 · PMID 42522262 · doi:10.1093/jimmun/vkag202
This dataset
Open GSE310048 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310048_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1365061 and SRA study SRP644955. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42522262) ↗
Study design
2 × Peripheral CD8+ T cells, siDUSP2 transfected, healthy dono vs 2 × Peripheral CD8+ T cells, siControl transfected, healthy dono vs 2 × Peripheral CD8+ T cells, siDUSP2 transfected, anti-CD3/CD28 activated, 24-hours, healthy dono vs 2 × Peripheral CD8+ T cells, siControl transfected, anti-CD3/CD28 activated, 24-hours, healthy dono

Supports a between-group comparison across 8 samples.

How we read this: 4 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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