GEO series
The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice
GSE310090
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2026/03/31
GPL34328
Summary
We previously described the synthesis and characterization of SK-124, a pharmacologic SIK2/SIK3 inhibitor that increases trabecular bone formation in eugonadal mice. However, the efficacy of this agent in osteoporosis mouse models remains unknown. In this study, we investigated the therapeutic potential of SK-124 in a male hypogonadal bone loss model (orchiectomy, ORX) in BALB/c male mice.Bone RNA-sequencing analysis demonstrated novel pathways associated with increased bone formation in response to SK-124 treatment.
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Paper (PMID 41908158) ↗
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