The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × Sham vehicle vs 4 × ORX vehicle vs 4 × ORX SKGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male miceJBMR plus · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310090_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1365103 and SRA study SRP645371. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9287971 Sham vehicle1 Sham vehicle
- GSM9287972 Sham vehicle2 Sham vehicle
- GSM9287973 Sham vehicle3 Sham vehicle
- GSM9287974 Sham vehicle4 Sham vehicle
- GSM9287975 ORX vehicle1 ORX vehicle
- GSM9287976 ORX vehicle3 ORX vehicle
- GSM9287977 ORX vehicle4 ORX vehicle
- GSM9287978 ORX vehicle7 ORX vehicle
- GSM9287979 ORX SK1 ORX SK
- GSM9287980 ORX SK3 ORX SK
- GSM9287981 ORX SK4 ORX SK
- GSM9287982 ORX SK5 ORX SK
- GSE285777 The SIK2/SIK3 inhibitor GLPG3970 increases bone formation and trabecular bone mass in hypogonadal female mice and rats 9 samples shares sik2, sik3, hypogonadal, inhibitor, increases
- GSE234221 Comprehensive transcriptome analysis of osteoclasts with the SIK3 deletion and pterosin B treatment. 15 samples shares sik3
- GSE278753 Effects of SIK3 KO on the transcriptome in CA1 region 8 samples shares sik3
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.