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Effects of SIK3 KO on the transcriptome in CA1 region

GSE278753 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/06/11 Platform GPL24247
Summary
SIK3 is reported to regulate sleep in mice, but it's unclear how SIK3 works at the synapse in the brain. Here, to explore the potential effects of endogenous SIK3 on the global transcriptome, in-vivo deletion of SIK3 was achieved by CRISPR KO in the CA1 region of Cas9 mice. The CA1 tissues were dissected and analyzed by bulk RNAseq. The result shows that in-vivo deletion of SIK3 induces a minor change in the transcriptome, suggesting a transcription-independent mechanism for SIK3.
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Direct links to NCBI, no account and no request form: the whole study as GSE278753_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1168572 and SRA study SRP536462. Searching any of these in the dataset finder brings you back here.

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