← BioTransfer GEO Dataset Finder
GEO series

Role of MYOC A445V mutation on glaucomatous degeneration of human retinal ganglion cells.

GSE310484 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/01 Platform GPL21697
Summary
Glaucoma is a group of diseases that results in the death of retinal ganglion cells (RGCs), leading to permanent blindness. Myocilin is one of the genetic factors associated with primary open angle glaucoma (POAG) with or without ocular hypertension. Using myocilin-dependent POAG patient-derived iPSC RGCs, we have shown that RGCs harboring the myocilin mutation (A445V) have dysregulated unfolded protein response with developmental and functional abnormalities, which may make them suscepetible to degeneration regardless of ocular hypertension.
Published in
Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling
Shil SK, Subramani M, Van Hook MJ et al. · Stem cells (Dayton, Ohio) 2026 · PMID 41712748 · doi:10.1093/stmcls/sxag009
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE310484_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1366416 and SRA study SRP647550. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.