Studying the effect of sarcomeric MYH7R663H and non-sarcomeric BRAFT599R hypertrophic cardimyopathy mutations in human induced pluripotent stemm cell-derived cardiomyocytes
RNA-seq (gene expression) · human · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 5 × hiPSC-CMs, healthy, vs 5 × hiPSC-CMs, BRAFT599R, vs 5 × hiPSC-CMs, MYH7R663H,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mavacamten improves energy balance in a pre-clinical model of RASopathy-associated hypertrophic cardiomyopathyPediatric research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE332763_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1469061 and SRA study SRP702643. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 3 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9753043 hiPSC-CMs, healthy, rep1 hiPSC-CMs, healthy,
- GSM9753044 hiPSC-CMs, healthy, rep2 hiPSC-CMs, healthy,
- GSM9753045 hiPSC-CMs, healthy, rep3 hiPSC-CMs, healthy,
- GSM9753046 hiPSC-CMs, healthy, rep4 hiPSC-CMs, healthy,
- GSM9753047 hiPSC-CMs, healthy, rep5 hiPSC-CMs, healthy,
- GSM9753048 hiPSC-CMs, BRAFT599R, rep1 hiPSC-CMs, BRAFT599R,
- GSM9753049 hiPSC-CMs, BRAFT599R, rep2 hiPSC-CMs, BRAFT599R,
- GSM9753050 hiPSC-CMs, BRAFT599R, rep3 hiPSC-CMs, BRAFT599R,
- GSM9753051 hiPSC-CMs, BRAFT599R, rep4 hiPSC-CMs, BRAFT599R,
- GSM9753052 hiPSC-CMs, BRAFT599R, rep5 hiPSC-CMs, BRAFT599R,
- GSM9753053 hiPSC-CMs, MYH7R663H, rep1 hiPSC-CMs, MYH7R663H,
- GSM9753054 hiPSC-CMs, MYH7R663H, rep2 hiPSC-CMs, MYH7R663H,
- GSM9753055 hiPSC-CMs, MYH7R663H, rep3 hiPSC-CMs, MYH7R663H,
- GSM9753056 hiPSC-CMs, MYH7R663H, rep4 hiPSC-CMs, MYH7R663H,
- GSM9753057 hiPSC-CMs, MYH7R663H, rep5 hiPSC-CMs, MYH7R663H,
- GSE262419 Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 4558 samples shares cardiomyocytes, cell-derived, pluripotent
- GSE293391 Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones 18 samples shares cardiomyocytes, cell-derived, pluripotent
- GSE326195 Oxygen-generating microparticles enhance viability and functionality of human pluripotent stem cell-derived cardiomyocytes 14 samples shares cardiomyocytes, cell-derived, pluripotent
- GSE314271 RNA-seq analysis of PAPD5 inhibitor effects in expanded human induced pluripotent stem cell-derived cardiomyocytes 13 samples shares cardiomyocytes, cell-derived, pluripotent
- GSE261296 YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes 12 samples shares cardiomyocytes, cell-derived, pluripotent
- GSE336395 Multi-omic analysis reveals maturation programs in human pluripotent stem cell-derived cardiomyocytes during long-term culture 11 samples shares cardiomyocytes, cell-derived, pluripotent
- GSE279695 Metabolic changes of human induced pluripotent stem cell-derived cardiomyocytes and teratomas after transplantation 9 samples shares cardiomyocytes, cell-derived, pluripotent
- GSE323990 Effects of RRAGD p.(Ser76Leu) variant in human induced pluripotent stem cell-derived cardiomyocytes gene expression 8 samples shares cardiomyocytes, cell-derived, pluripotent
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.