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Characterizing breast cancer cell biochemical responses to fluid shear in a 3D loading model

GSE310741 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/25 Platform GPL34281
Summary
Bone is the most common site of breast cancer metastasis—only 12% of patients with skeletal metastases demonstrate a 5-year survival rate after diagnosis. Bone metastasis is characterized by a vicious cycle, where tumor-secreted factors results in increased bone turnover that often favors net bone loss. Mechanical loading, typically a bone anabolic and osteoprotective stimulus, has been shown to have positive effects on osteolytic lesions in vivo. However, the underlying mechanisms are still under investigation. Full characterization of the tumor-secreted factors that influence cancer-induced osteolysis will improve our understanding of atypical bone remodeling and mechanoresponses in tumor-induced bone disease.
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Direct links to NCBI, no account and no request form: the whole study as GSE310741_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1367013 and SRA study SRP647268. Searching any of these in the dataset finder brings you back here.

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