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Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization [ChIP-Seq]

GSE310749 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/01/09 Platform GPL21626
Summary
Neuronal activity induces gene expression programs associated with plasticity in the brain, but it also transiently suppresses gene expression through poorly understood mechanisms. Here, we report that neuronal activity downregulates NEUROD-dependent gene expression in cerebellar granule neurons in adult mice. Using NEUROD1/2 double conditional knockout mice of both sexes, we show that NEUROD binds and activates its target gene enhancers and establishes a three-dimensional genome architecture that facilitates transcription when neuronal activity is low. Moreover, NEUROD antagonizes activity-dependent gene expression programs, including those regulated by MEF2. However, when granule neurons are activated, NEUROD-dependent transcriptional and genome organizing functions are disrupted. Together, these findings reveal NEUROD as a key regulator of transcriptional programs associated with inactive neurons. Our study provides new insights into how neuronal activity reshapes gene transcription and genome architecture in the brain.
Published in
Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization
Valnegri P, Yamada T, Yang Y · The Journal of neuroscience : the official journal of the Society for Neuroscience 2026 · PMID 41513463 · doi:10.1523/JNEUROSCI.1565-25.2025
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Also filed as BioProject PRJNA1367031 and SRA study SRP647252. Searching any of these in the dataset finder brings you back here.

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