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Chidamide and Anlotinib act synergistically in Jurkat cells by inhibiting the Hippo signaling pathway

GSE310869 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/11/24 Platform GPL24676
Summary
T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive hematologic malignancy characterized by drug resistance, relapse and poor prognosis. Chidamide, a histone deacetylase inhibitor, has shown epigenetic therapeutic potential in T-ALL, but its efficacy is limited and acquired drug resistance exists. To overcome these limitations, we systematically evaluated the synergistic Combination effects of three drug candidates, OTX-015 (BET inhibitor), Metformin (metabolic regulator), and Anlotinib (multitargeted tyrosine kinase inhibitor), with Chidamide.
Published in
Chidamide and Anlotinib act synergistically in Jurkat cells by inhibiting the Hippo signaling pathway
Ma T, Yu Y, Yang S et al. · Biochemistry and biophysics reports 2026 · PMID 41631215 · doi:10.1016/j.bbrep.2026.102469
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Also filed as BioProject PRJNA1367378 and SRA study SRP647444. Searching any of these in the dataset finder brings you back here.

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