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Harnessing lipid-driven immuno-metabolic pathways in omental metastases to enhance immunotherapy in ovarian cancer

GSE310918 Mus musculus Expression profiling by high throughput sequencing; Other 4 samples Submitted 2025/12/19 Platform GPL24247
Summary
Despite the potential of immune checkpoint blockade (ICB) in epithelial ovarian carcinoma (EOC), its clinical efficacy remains limited. Our study investigates the immuno-metabolic landscape of omental metastases to identify therapeutic targets. Using patient-derived explants (PDEs), we demonstrate that lipid-rich omental environments preserve effector T cell function, while lipid processing in tumor-associated macrophages (TAMs) induces oxidative stress and immune suppression. Targeting lipid metabolism via CCR5 inhibition (e.g., maraviroc) or anti-CD36 treatment reprograms TAMs, restores T cell activity, and enhances anti-tumor immunity. These findings reveal a metabolic-inflammatory axis that can be modulated to improve ICB outcomes in EOC.
Published in
Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer
Suarez-Carmona M, Hampel M, Zhang XW et al. · Signal transduction and targeted therapy 2026 · PMID 41775684 · doi:10.1038/s41392-026-02594-8
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Also filed as BioProject PRJNA1367533 and SRA study SRP647516. Searching any of these in the dataset finder brings you back here.

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