Integrated Transcriptomic and Functional Analysis Reveals Tissue-Specific Molecular Pathology in Adolescent Idiopathic Scoliosis
RNA-seq (gene expression) · human · 21 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 21 samples: 8 × AIS, muscle, concave, patient vs 8 × AIS, muscle, convex, patient vs 5 × control, muscle, patientGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrated transcriptomic and functional analysis reveals tissue-specific molecular pathology in adolescent idiopathic scoliosisHGG advances · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE311180_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1368770 and SRA study SRP648483. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 21 samples.
How we read this: 3 replicated groups read from 21 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9320745 AIS, muscle, concave, patient 1 AIS, muscle, concave, p…
- GSM9320746 AIS, muscle, concave, patient 2 AIS, muscle, concave, p…
- GSM9320747 AIS, muscle, concave, patient 3 AIS, muscle, concave, p…
- GSM9320748 AIS, muscle, concave, patient 4 AIS, muscle, concave, p…
- GSM9320749 AIS, muscle, concave, patient 5 AIS, muscle, concave, p…
- GSM9320750 AIS, muscle, concave, patient 6 AIS, muscle, concave, p…
- GSM9320751 AIS, muscle, concave, patient 7 AIS, muscle, concave, p…
- GSM9320752 AIS, muscle, concave, patient 8 AIS, muscle, concave, p…
- GSM9320753 AIS, muscle, convex, patient 2 AIS, muscle, convex, pa…
- GSM9320754 AIS, muscle, convex, patient 3 AIS, muscle, convex, pa…
- GSM9320755 AIS, muscle, convex, patient 4 AIS, muscle, convex, pa…
- GSM9320756 AIS, muscle, convex, patient 5 AIS, muscle, convex, pa…
- GSM9320757 AIS, muscle, convex, patient 6 AIS, muscle, convex, pa…
- GSM9320758 AIS, muscle, convex, patient 8 AIS, muscle, convex, pa…
- GSM9320759 AIS, muscle, convex, patient 9 AIS, muscle, convex, pa…
- GSM9320760 AIS, muscle, convex, patient 10 AIS, muscle, convex, pa…
- GSM9320761 control, muscle, patient 1 control, muscle, patient
- GSM9320762 control, muscle, patient 2 control, muscle, patient
- GSM9320763 control, muscle, patient 3 control, muscle, patient
- GSM9320764 control, muscle, patient 4 control, muscle, patient
- GSM9320765 control, muscle, patient 5 control, muscle, patient
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.