Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 18 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 14 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell agingThe Journal of experimental medicine · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE311225_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1368776 and SRA study SRP460768. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 18 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7783461 ON_Old1A
- GSM7783462 ON_Old1B
- GSM7783463 ON_Old1C
- GSM7783464 ON_Old2A
- GSM7783465 ON_Old2B
- GSM7783466 ON_Old2C
- GSM7783467 ON_Young1A
- GSM7783468 ON_Young1B
- GSM7783469 ON_Young1C
- GSM7783470 ON_Young2A
- GSM7783471 ON_Young2B
- GSM7783472 ON_Young2C
- GSM9321411 HIGH1
- GSM9321413 HIGH2
- GSM9321414 HIGH3
- GSM9321415 LOW1
- GSM9321416 LOW2
- GSM9321418 LOW3
- GSE225012 The nuclear cap-binding complex safeguards stress-resistant protein synthesis and proliferation of stem cells 24 samples shares proliferation, stress, stem
- GSE234237 Transposable Elements Shape Stemness in Normal and Leukemic Hematopoiesis 215 samples shares hematopoiesis, stem
- GSE26143 Senescence-correlated gene expression programs of human prostate stromal cells in response to multiple proliferation-arresting stress and their potential in driving prostate neoplasia 12 samples shares proliferation, stress
- GSE87515 The m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-Like Cells by Sustaining FOXM1 Expression and Cell Proliferation Programing 8 samples shares proliferation, stem
- GSE272205 3D porous microscaffold promoted hPSC-macrophage large-scale production by facilitating proliferation and self-renewal gene network 54 samples shares proliferation
- GSE210432 TET2 Mutant Clonal Hematopoiesis Enhances Severity of COVID-19 Related Cytokine Release Syndrome and is Associated with Increased Mortality [scMULT] 36 samples shares hematopoiesis
- GSE299801 AS04 drives superior cross-protective antibody response by increased NOTCH signaling of Dendritic Cells and proliferation of memory B cells 16 samples shares proliferation
- GSE295277 Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity [Human_Mulitome_Cohort1] 14 samples shares hematopoiesis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.