GEO series
RNA-seq profiling of ADAM10 inhibition in DLD-1 and SW620 colorectal cancer cell lines
GSE311253
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/01/19
GPL34281
Summary
This study examines the transcriptomic effects of ADAM10 inhibition in two human colorectal cancer cell lines, DLD-1 and SW620. Cells were treated with vehicle control or the conformation-specific ADAM10 monoclonal antibody 1H5 for 48 hours, followed by extraction of total RNA and paired-end RNA sequencing. The dataset enables comparative analysis of ADAM10-regulated pathways across different CRC genetic backgrounds, including alterations in Notch and EGFR signaling, metabolic gene programs, and other pathways associated with tumor progression.
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Paper (PMID 41675514) ↗
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