RNA-seq profiling of ADAM10 inhibition in DLD-1 and SW620 colorectal cancer cell lines
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × DLD-1, CNT vs 3 × DLD-1, 1H5 vs 3 × SW620, CNT vs 3 × SW620, 1H5Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Inhibition of colorectal cancer progression through conformation-specific targeting of ADAM10 metalloproteaseFrontiers in oncology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE311253_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1368855 and SRA study SRP648579. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9322417 DLD-1, CNT_1 DLD-1, CNT
- GSM9322418 DLD-1, CNT_2 DLD-1, CNT
- GSM9322419 DLD-1, CNT_3 DLD-1, CNT
- GSM9322420 DLD-1, 1H5_1 DLD-1, 1H5
- GSM9322421 DLD-1, 1H5_2 DLD-1, 1H5
- GSM9322422 DLD-1, 1H5_3 DLD-1, 1H5
- GSM9322423 SW620, CNT_1 SW620, CNT
- GSM9322424 SW620, CNT_2 SW620, CNT
- GSM9322425 SW620, CNT_3 SW620, CNT
- GSM9322426 SW620, 1H5_4 SW620, 1H5
- GSM9322427 SW620, 1H5_5 SW620, 1H5
- GSM9322428 SW620, 1H5_6 SW620, 1H5
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal, rna-seq
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE254323 RNA-seq of colorectal cancer cell line HCT116 and DLD-1 cells treated with PRIMA-1met or oxaliplatin or combination therapy 24 samples shares dld-1, colorectal, rna-seq
- GSE298581 Global gene expression response to PPARG inhibition in three urothelial cancer cell lines 48 samples shares inhibition, lines
- GSE323965 Transcriptional signatures indicating RB function may predict response to CDK4/6 inhibition in endometrial cancer [RNA-Seq] 39 samples shares inhibition, rna-seq
- GSE275078 In vitro drug screening of RAF/MEK/ERK Inhibitors in combination with Autophagy inhibition in the context of two PDA Cell Lines 136 samples shares inhibition, lines
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.