← BioTransfer GEO Dataset Finder
GEO series

SnRNA seq revealed astrocytic MAGL-KO rescued cognitive impairments in 5xFAD mice

GSE311467 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/02/20 Platform GPL24247
Summary
In the brain, 2-Arachidonoylglycerol (2-AG) is the most abundant endogenous cannabinoid. Enhancing 2-AG signaling by inhibiting monoacylglycerol lipase (MAGL) in astrocytes, the primary enzyme that degrades 2-AG in the brain, produces anti-inflammatory and neuroprotective effects in neurodegenerative diseases. However, the effects of astrocytic MAGL inhibition in 5xFAD mice were still unclear. To address this question, behavioral tests were performed and hippocampal nuclei were isolated from WT, TG, TG-aKO, TG-nKO, and TG-tKO mice. Our behavioral and electrophysiological results showed that cognitive and synaptic functions were rescued in TG-aKO mice. Using single-nucleus RNA sequencing analysis, we show here that neuronal MAGL KO mice display distinct gene expression profiles of synaptic DEGs in neurons and glial cells
Published in
Selective Inactivation of Astrocytic Monoacylglycerol Lipase for Alzheimer's Disease Therapy
Sun L, Hu M, Lyu J et al. · bioRxiv : the preprint server for biology 2025 · PMID 41427297 · doi:10.64898/2025.12.04.692105
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE311467_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1369509 and SRA study SRP648959. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 5 more — browse all 5 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.