RNA sequencing for gastric-type endocervical adenocarcinoma (GAS), usual-type endocervical adenocarcinoma (UEA), and lobular endocervical glandular hyperplasia (LEGH)

Cervical cancer is the fourth most common malignancy among women worldwide. While the majority of cases are human papillomavirus (HPV)-associated squamous cell carcinomas, a subset consists of adenocarcinomas. Uterine cervical adenocarcinoma is further classified into gastric-type adenocarcinoma (GAS), usual-type endocervical adenocarcinoma (UEA), and other subtypes. Lobular endocervical glandular hyperplasia (LEGH), a non-neoplastic glandular lesion, has been proposed as a potential precursor of GAS. In this study, we investigated the gene expression profiles of GAS, UEA, and LEGH using RNA sequencing.