GEO series
E96A TMZ Treatment Study
GSE311738
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/02/04
GPL24676
Summary
Temozolomide (TMZ) induces DNA alkylation lesions repaired primarily through base excision repair. To characterize transcriptional responses to TMZ in the context of impaired APE1 endonuclease activity, RNA-seq was performed on Pa03C Cas9 and E96A mutant cell lines following treatment. Cells were treated with TMZ for 4 hours or 8 hours, along with untreated controls. This dataset captures genotype-specific and time-dependent transcriptional responses to alkylation stress in PDAC cells.
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Paper (PMID 41510226) ↗
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