GEO series
Tumour endothelial cells transcriptomics in response to Doxorubicin treatment.
GSE311784
Mus musculus
Expression profiling by high throughput sequencing
28 samples
2026/07/01
GPL19057
Summary
Despite its established role in breast cancer treatment, Doxorubicin remains a challenge in breast cancer treatment as its long-term success is prevented by adaptive resistance mechanisms that extend beyond cancer cell intrinsic alterations. Our study in a MMTV-PyMT-driven mouse breast cancer model reveals that prolonged Doxorubicin exposure triggers a significant reprogramming of the tumour vasculature, substantially altering the angiocrine landscape and shaping treatment outcomes.
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Paper (PMID 42329467) ↗
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