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Transcriptome profiling of hPDLSCs following Enterococcus LTA stimulation

GSE311844 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/28 Platform GPL24676
Summary
This study investigates gene expression changes in human periodontal ligament stem cells (hPDLSCs) following exposure to microbial components. hPDLSCs were cultured under osteogenic induction conditions and treated with Enterococcus-derived lipoteichoic acid (LTA) at 10 μg/mL for 7 days. Total RNA was extracted and subjected to RNA-seq on the Illumina NovaSeq 6000 platform. The processed data include gene-level FPKM expression values. These data provide a resource for exploring how microbial components influence the transcriptional responses of hPDLSCs under osteogenic induction.
Published in
Olanzapine affects bone formation via oral Enterococcus through SAA1 gene and extracellular matrix-related pathways
Yuan H, Wang MY, Liu RX et al. · Frontiers in cellular and infection microbiology 2025 · PMID 41568002 · doi:10.3389/fcimb.2025.1673931
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Direct links to NCBI, no account and no request form: the whole study as GSE311844_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1370464. Searching any of these in the dataset finder brings you back here.

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