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Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs AML chemoresistance

GSE311903 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/03 Platform GPL34284
Summary
Despite extensive research and intensive use of chemotherapies in clinics, the 5-year overall survival of Acute Myeloid Leukemia (AML) patients does not exceed 20%. The clonal expansion of leukemic blasts leads to modifications of the bone marrow physical properties, including increased extracellular matrix stiffening, upregulation of intramedullary pressure and reduction of the space available for cells. These biomechanical modifications are speculated to alter therapeutic response and cause treatment resistance. This project aims to decipher the role of mechanotransduction pathways in specially the Hippo pathway in resistant AML.
Published in
Targeting BMP and TAZ/TEAD mechanotransduction pathways impairs acute myeloid leukemia chemoresistance
Barral L, Lespinasse N, Martin Cardozo C et al. · Leukemia 2026 · PMID 41851473 · doi:10.1038/s41375-026-02904-7
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Also filed as BioProject PRJNA1371915 and SRA study SRP650163. Searching any of these in the dataset finder brings you back here.

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