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Differential transcriptional effects of mycobacterial nucleomodulins MgdE and MmpE in THP-1 macrophages

GSE312039 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/05 Platform GPL24676
Summary
This study uses RNA-seq to quantitatively compare the gene expression profiles of THP-1 macrophages infected with the wild-type (WT), mgdE-deleted (ΔmgdE), and mmpE-deleted (ΔmmpE) strains of Mycobacterium bovis BCG, in order to investigate the roles of two conserved nucleomodulins, MgdE (Rv1075c) and MmpE (Rv2577), in host-pathogen interactions.
Published in
Mycobacterial metallophosphatase MmpE acts as a nucleomodulin to regulate host gene expression and promote intracellular survival
Chen L, Duan B, Jiang Q et al. · eLife 2026 · PMID 41848417 · doi:10.7554/eLife.108037
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Direct links to NCBI, no account and no request form: the whole study as GSE312039_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1372087 and SRA study SRP650396. Searching any of these in the dataset finder brings you back here.

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