GEO series
Ramulus Mori (Sangzhi) Alkaloids Attenuate Diet-Induced Obesity by Promoting White Adipose Browning and Enhancing Brown Fat Thermogenesis
GSE312093
Mus musculus
Expression profiling by high throughput sequencing
43 samples
2025/12/04
GPL24247
Summary
Obesity is a chronic metabolic disorder characterized by excessive adipose accumulation and is closely associated with type 2 diabetes mellitus (T2DM), cardiovascular diseases, and metabolic dysfunction associated steatotic liver disease. Enhancing adipose thermogenic capacity has emerged as a promising strategy to counteract obesity. Ramulus Mori (Sangzhi) alkaloids (SZ-A), a natural alkaloid complex clinically approved for T2DM, exhibit multiple metabolic benefits, but their anti-obesity mechanisms remain unclear.
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