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Hepatocyte angiotensinogen deletion protects against Western diet-induced adiposity and hepatic steatosis under thermoneutral housing

GSE338380 Mus musculus (mouse) RNA-seq (gene expression) 48 samples Submitted 2026/08/05 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 48 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
48 samples: 12 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Summary (written by the submitters)
Room-temperature housing imposes adaptive cold stress in mice and can alter brown adipose tissue activity and systemic energy expenditure. This study tested whether hepatocyte-specific Agt deletion protects against Western diet-induced metabolic dysfunction under thermoneutral housing. Male hepAGT-/- and hepAGT+/+ littermate mice were housed at room temperature or thermoneutrality and fed a Western diet for 12 weeks.
Read the full summary ↓
Liver, brown adipose tissue, and epididymal white adipose tissue were collected for bulk RNA-seq to define tissue-specific transcriptional programs associated with hepatocyte angiotensinogen deletion and thermal environment.
This dataset
Open GSE338380 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE338380_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1494419 and SRA study SRP717506. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Study design
12 conditions, mostly with about 4 replicates each
hepAGT-/-, brown adipose tissue, room tempera… ×4 hepAGT-/-, epididymal white adipose tissue, r… ×4 hepAGT-/-, liver, room temperature, Western d… ×4 hepAGT+/+, brown adipose tissue, room tempera… ×4 hepAGT+/+, epididymal white adipose tissue, r… ×4 hepAGT+/+, liver, room temperature, Western d… ×4 hepAGT-/-, brown adipose tissue, thermoneutra… ×4 hepAGT-/-, epididymal white adipose tissue, t… ×4 +4 more

Supports a between-group comparison across 48 samples.

How we read this: 12 replicated groups read from 48 sample titles; they account for 48 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 8 more — browse all 48 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.