Gene silencing of ANGPTL3 suppresses α1-antitrypsin and lectin mannose-binding 1 expression in the hepatoma Huh7 cell line
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × CTRL vs 3 × Ang3 vs 3 × PCSK9 vs 3 × A3P9Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Gene Silencing of ANGPTL3 Induces PCSK9: Exploring the Biological Significance in the Hepatoma Huh7 Cell LineCells · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE312289_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1372774 and SRA study SRP650845. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9342780 CTRL1 CTRL
- GSM9342781 CTRL2 CTRL
- GSM9342782 CTRL3 CTRL
- GSM9342783 Ang3_1 Ang3
- GSM9342784 Ang3_2 Ang3
- GSM9342785 Ang3_3 Ang3
- GSM9342786 PCSK9-1 PCSK9
- GSM9342787 PCSK9-2 PCSK9
- GSM9342788 PCSK9-3 PCSK9
- GSM9342789 A3P9-1 A3P9
- GSM9342790 A3P9-2 A3P9
- GSM9342791 A3P9-3 A3P9
- GSE227083 CDK16 and CDK18 inhibition suppresses nuclear pore-mediated DNA repair and hepatocellular carcinoma [Huh7] 33 samples shares huh7, suppresses
- GSE255384 RNA-sequencing of alpha beta hydrolase domain 6 (ABHD6) wild type (WT) versus knockout (KO) Huh7 hepatoma cells with or without palmitic acid treatment. 24 samples shares huh7, hepatoma
- GSE334407 Physiologically relevant media are associated with overlapping metabolic responses in primary human hepatocytes and Huh7 cells 30 samples shares huh7
- GSE293320 Transcriptome data of Huh7 cells treated with glucose or fructose 24 samples shares huh7
- GSE324107 Comparable Transcriptomic Profiles of HepaRG and HuH7 Cells Cultured in Chemically Defined and Serum-Based Media Using Primary Human Hepatocytes as Reference 20 samples shares huh7
- GSE266041 Sequencing of human hepatocellular carcinoma huh7 cell line under the effect of disulfiram [transcriptome] 12 samples shares huh7
- GSE221371 ANGPTL3 regulates the peroxisomal translocation of SmarcAL1 in response to cell growth states 12 samples shares angptl3
- GSE298810 Transcriptomic profiles of Huh7 and HLF hepatocellular carcinoma cells under 2D and 3D culture conditions 12 samples shares huh7
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.