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Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging

GSE312362 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/18 Platform GPL24676
Summary
To investigate the role S100A7, a skin-derived antimicrotial peptide (AMP) in skin aging, we knockdowned S100A7 in normal human keratinocytes, which induced senescence markers, impaired autophagy, and partially recapitulated aging-associated transcriptional changes. Conversely, supplementation with physiological levels of S100A7 restored autophagic flux and attenuated senescence in D-galactose–induced aging models. These findings identify S100A7 as a molecular link between epidermal differentiation, autophagy, and cellular senescence, establishing an AMP–autophagy axis in skin aging.
Published in
Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging
Peng G, Hattori F, Ogawa H et al. · npj aging 2026 · PMID 41547977 · doi:10.1038/s41514-026-00330-8
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Also filed as BioProject PRJNA1373180. Searching any of these in the dataset finder brings you back here.

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