GEO series
Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment
GSE312549
Homo sapiens
Expression profiling by high throughput sequencing
14 samples
2026/02/26
GPL11154
Summary
In human neuroblastoma cell lines, absence of baseline cGAS expression and lack of cGAS induction upon stimulation by cytosolic DNA has been reported, whereas the functionality of the cGAS-STING pathway in primary neuroblastoma has remained uncertain. To assess whether cGAS-STING pathway may be active in human neuroblastoma, we analyzed CGAS expression in primary tumor samples and compared it with that in human neuroblastoma cell lines.
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Paper (PMID 41948996) ↗
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