Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 179 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 179 samples: 75 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disordersMolecular cell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE312574_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1374195 and SRA study SRP556311. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 150 samples.
How we read this: 75 replicated groups read from 179 sample titles; they account for 150 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8722833 mESC ,Clone R70H 112 ,Replicate 1 mESC ,Clone R70H 112 ,
- GSM8722834 mESC ,Clone R70H 112 ,Replicate 2 mESC ,Clone R70H 112 ,
- GSM8722835 mESC ,Clone R70H 282 ,Replicate 1 mESC ,Clone R70H 282 ,
- GSM8722836 mESC ,Clone R70H 282 ,Replicate 2 mESC ,Clone R70H 282 ,
- GSM8722837 mESC ,WT ,Replicate 1 mESC ,WT ,
- GSM8722838 mESC ,WT ,Replicate 2 mESC ,WT ,
- GSM8722839 mNPC ,Clone R70H 112 ,Replicate 1 mNPC ,Clone R70H 112 ,
- GSM8722840 mNPC ,Clone R70H 112 ,Replicate 2 mNPC ,Clone R70H 112 ,
- GSM8722841 mNPC ,Clone R70H 282 ,Replicate 1 mNPC ,Clone R70H 282 ,
- GSM8722842 mNPC ,Clone R70H 282 ,Replicate 2 mNPC ,Clone R70H 282 ,
- GSM8722843 mNPC ,WT ,Replicate 1 mNPC ,WT ,
- GSM8722844 mNPC ,WT ,Replicate 2 mNPC ,WT ,
- GSM8722845 mNeuronDiff ,Clone R70H 112 ,Replicate 1 mNeuronDiff ,Clone R70H…
- GSM8722846 mNeuronDiff ,Clone R70H 112 ,Replicate 2 mNeuronDiff ,Clone R70H…
- GSM8722847 mNeuronDiff ,Clone R70H 282 ,Replicate 1 mNeuronDiff ,Clone R70H…
- GSM8722848 mNeuronDiff ,Clone R70H 282 ,Replicate 2 mNeuronDiff ,Clone R70H…
- GSM8722849 mNeuronDiff ,WT ,Replicate 1 mNeuronDiff ,WT ,
- GSM8722850 mNeuronDiff ,WT ,Replicate 2 mNeuronDiff ,WT ,
- GSM8722851 ESC, WT, Replicate licate 1
- GSM8722852 ESC, WT, Replicate 2
- GSM8722853 ESC, R70H, Replicate 1 ESC, R70H,
- GSM8722854 ESC, R70H, Replicate 2 ESC, R70H,
- GSM8722855 NPC, WT, Replicate 1 NPC, WT,
- GSM8722856 NPC, WT, Replicate 2 NPC, WT,
- GSM8722857 NPC, R70H, Replicate 1 NPC, R70H,
- GSM8722858 NPC, R70H, Replicate 2 NPC, R70H,
- GSM8722859 mESC WT, Input, Replicate 1 mESC WT, Input,
- GSM8722860 mESC WT, Input, Replicate 2 mESC WT, Input,
- GSM8722861 mESC WT, H3K27me3, Replicate 1 mESC WT, H3K27me3,
- GSM8722862 mESC WT, H3K27me3, Replicate 2 mESC WT, H3K27me3,
- GSM8722863 mESC WT, H2A, Lys119, Replicate 1 mESC WT, H2A, Lys119,
- GSM8722864 mESC WT, H2A, Lys119, Replicate 2 mESC WT, H2A, Lys119,
- GSM8722865 mESC WT, Ring1b, Replicate 1 mESC WT, Ring1b,
- GSM8722866 mESC WT, Ring1b, Replicate 2 mESC WT, Ring1b,
- GSM8722867 mESC R70H, Input, Replicate 1 mESC R70H, Input,
- GSM8722868 mESC R70H, Input, Replicate 2 mESC R70H, Input,
- GSM8722869 mESC R70H, H3K27me3, Replicate 1 mESC R70H, H3K27me3,
- GSM8722870 mESC R70H, H3K27me3, Replicate 2 mESC R70H, H3K27me3,
- GSM8722871 mESC R70H, H2A, Lys119, Replicate 1 mESC R70H, H2A, Lys119,
- GSM8722872 mESC R70H, H2A, Lys119, Replicate 2 mESC R70H, H2A, Lys119,
+ 139 more — browse all 179 samples with per-sample file links →
- GSE221699 Chromatin Remodeling Drives Immune-Fibroblast Cell Communication in Heart Failure 57 samples shares chromatin, drives
- GSE278946 cPRC1.2 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation 43 samples shares chromatin, drives
- GSE295888 SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging. 30 samples shares chromatin, binding
- GSE324908 Alternative splicing-triggered mRNA decay informs splice-switching targets for neurodevelopmental disorders 14 samples shares neurodevelopmental, disorders
- GSE13084 Mapping polycomb complexes in human and mouse embryonic stem cells 8 samples shares complexes, polycomb
- GSE274495 The remodeling of bivalent chromatin is essential for mouse peri-implantation embryogenesis. 421 samples shares chromatin
- GSE336954 Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder 126 samples shares chromatin
- GSE295715 Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness 90 samples shares chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.