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A Titin Missense Variant Causes Atrial Fibrillation

GSE312917 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/08 Platform GPL24676
Summary
A single TTN point mutation- a missense variant ( TTN-T32756I) can impair sarcomere integrity and lead to atrial electrical remodeling, increasing AF- A link that needs investigation
Published in
A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation
Pavel MA, Chen H, Hill M et al. · eLife 2026 · PMID 41569083 · doi:10.7554/eLife.104719
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Also filed as BioProject PRJNA1377605 and SRA study SRP653469. Searching any of these in the dataset finder brings you back here.

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