GEO series
Prime Editing Enables Isogenic Modeling of PNPLA3-I148M-Associated Lipotoxicity in Hepatocytes
GSE313544
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2026/07/01
GPL35417
Summary
We demonstrate that prime editing enables a precise approach for modeling PNPLA3-I148M in human hepatocytes, offering a platform to investigate genotype-specific cellular responses. By combining precise genome editing with human cell modeling, this study provides new insight into the biology of a key risk allele and establishes a platform for personalized therapeutic strategies targeting genetically defined subgroups of liver disease.
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