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Transcriptomic profiling of TREM2⁺ and TREM2⁻ TAMs in mouse HCC [RNA-seq]

GSE313559 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/29 Platform GPL24247
Summary
Immune-checkpoint blockade (ICB) therapies have transformed the treatment landscapes of solid malignancies, including hepatocellular carcinoma (HCC), which is currently the sixth most common cancer and the third leading cause of cancer death worldwide. Despite unprecedented success in clinical trials, the immunosuppressive tumor microenvironment constructed by tumor cells restricts the responsiveness of ICB therapies to a minority of patients. Triggering receptor expressed on myeloid cells-2 (TREM2) counteracts inflammation and maintains metabolic fitness in myeloid cells. Emerging single-cell RNA sequencing data in different types of tumors have identified the significance of TREM2+ myeloid cells in tumor development and ICB resistance. In this study, we aimed to investigate the potential role of TREM2 in HCC ICB resistance.
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Direct links to NCBI, no account and no request form: the whole study as GSE313559_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1345504 and SRA study SRP632763. Searching any of these in the dataset finder brings you back here.

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