p300-Mediated Histone H3K18 Lactylation Promotes Mitochondrial ROS Accumulation via Mitophagy Inhibition to Potentiate Dopamine Agonists Efficacy in Prolactinomas [RNA-seq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × AtT-20 cells, B vs 3 × AtT-20 cells, L vs 3 × AtT-20 cells, NC vs 3 × AtT-20 cells, PGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- p300-mediated histone H3K18 lactylation promotes mitochondrial ROS accumulation via mitophagy inhibition to potentiate dopamine agonists efficacy in prolactinomasRedox biology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE313569_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1380325 and SRA study SRP654756. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9370479 AtT-20 cells, B-1 AtT-20 cells, B
- GSM9370480 AtT-20 cells, B-2 AtT-20 cells, B
- GSM9370481 AtT-20 cells, B-3 AtT-20 cells, B
- GSM9370482 AtT-20 cells, L-1 AtT-20 cells, L
- GSM9370483 AtT-20 cells, L-2 AtT-20 cells, L
- GSM9370484 AtT-20 cells, L-3 AtT-20 cells, L
- GSM9370485 AtT-20 cells, NC-1 AtT-20 cells, NC
- GSM9370486 AtT-20 cells, NC-2 AtT-20 cells, NC
- GSM9370487 AtT-20 cells, NC-3 AtT-20 cells, NC
- GSM9370488 AtT-20 cells, P-1 AtT-20 cells, P
- GSM9370489 AtT-20 cells, P-2 AtT-20 cells, P
- GSM9370490 AtT-20 cells, P-3 AtT-20 cells, P
- GSE335147 Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response 24 samples shares ros, mitochondrial, inhibition
- GSE291661 Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina [explant_RNA-seq] 12 samples shares h3k18, lactylation
- GSE291677 Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina 38 samples shares h3k18, lactylation
- GSE296797 CD38+CD93+ microglia and macrophages drive neuroinflammation through glycolysis-histone lactylation axis in multiple sclerosis model mice 17 samples shares ros, lactylation
- GSE291663 Lactate and histone H3K18 lactylation are associated with metabolic control of gene expression in the retina [explant_CUT&Tag] 10 samples shares h3k18, lactylation
- GSE319614 Bulk RNA-seq transcriptome profiling of hippocampus across 17 autism spectrum disorder mouse models 269 samples shares ros
- GSE332646 Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints 214 samples shares ros
- GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk 209 samples shares ros
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.