← BioTransfer GEO Dataset Finder
GEO series

Single-nucleus RNA sequencing and functional studies of acute methamphetamine-induced cognitive impairment

GSE313595 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/01 Platform GPL24247
Summary
Cognitive impairment is a hallmark phenotype of methamphetamine (Meth) abuse, yet the cellular mechanisms driving these deficits remain poorly understood. This study aims to investigate the cellular composition, gene expression profiles, key signaling pathways, intercellular communication networks, and transcription factor activity in hippocampal tissues from control mice and those acutely exposed to Meth, thereby elucidating the mechanistic underpinnings of Meth-induced neurotoxicity. Single-nucleus RNA sequencing (snRNA-seq) was employed to investigate the transcriptomes of nuclei isolated from the hippocampus of acute Meth-treated and control mice. Our study provides a systemic understanding of the transcriptome alterations induced by Meth exposure in mouse hippocampus, which may offer clues for therapeutic strategies against acute Meth exposure.
Published in
Single-nucleus RNA sequencing and functional studies of acute methamphetamine-induced cognitive impairment
An D, Lu F, Wang Y et al. · Communications biology 2026 · PMID 41699233 · doi:10.1038/s42003-026-09728-2
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE313595_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1380356 and SRA study SRP654806. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.