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Hepatic multilineage organoids derived from hypoimmunogenic iPSCs for liver regenerative medicine

GSE313725 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/03/26 Platform GPL30173
Summary
Hypoimmunogenic multicellular hepatic organoids were characterised by single-cell RNA sequencing to understand their cellular composition. Lineage cell identity was confirmed by gene and protein expression combined with ultrastructural analysis of cells by electron microscopy. Hepatic functional maturation was demonstrated by the production of liver-specific proteins, as shown by immunoassays. Together with the presence of a highly functional endothelial network, these properties confer therapeutic potential for inherited hepatic plasma protein deficiencies, end-stage liver disease and metabolic disorders.
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Direct links to NCBI, no account and no request form: the whole study as GSE313725_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1381506 and SRA study SRP655191. Searching any of these in the dataset finder brings you back here.

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