GEO series
RNA-seq of ISL1 overexpression during islet differentiation.
GSE313800
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
2025/12/23
GPL34281
Summary
This study aims to investigate the impact of ISL1 overexpression on hPSC-derived islet differentiation. hPSCs from four genotypes (WT, ISL1-/-, PDX1-/-, and PAX6-/-) were differentiated to pancreatic progenitors (day 11), transduced with ISL1-IRES2-BFP or BFP control lentivirus, and further differentiated to SC-islet (day 18). The BFP+ cells were isolated by flow cytometry sorting and subjected to RNA-seq to assess transcriptional responses to ISL1 overexpression across different genetic backgrounds.
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Paper (PMID 41509490) ↗
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