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Endotrophin and CD44-Mediated Heterotypic Signaling Mediates Tumor-Stroma Crosstalk and Facilitates Malignant Progression in Hepatocellular Carcinoma

GSE313961 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/05 Platform GPL24676
Summary
This study profiles gene expression changes in the human SK-Hep1 cell line, a mesenchymal-like liver-derived cell model, under conditions of differential sorafenib responsiveness. Bulk RNA sequencing was performed on sorafenib-sensitive (SS) and sorafenib-resistant (SR) cells treated with control siRNA (siCtrl), COL6A3 siRNA (siCOL6A3), or siCOL6A3 combined with recombinent endotrophin (rhETP). The data were generated to characterize transcriptional patterns associated with altered proliferation-and survival-related phenotypes across defined experimental conditions.
Published in
Endotrophin- and CD44-Mediated Heterotypic Signaling Mediates Tumor-Stroma Cross-talk and Facilitates Malignant Progression in Hepatocellular Carcinoma
Jo W, Park C, Kim M et al. · Cancer research 2026 · PMID 41671381 · doi:10.1158/0008-5472.CAN-25-3657
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Also filed as BioProject PRJNA1387435 and SRA study SRP655659. Searching any of these in the dataset finder brings you back here.

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