Uncoupling the two distinct roles of targeting BDCA2 in treating autoimmune diseases: direct inhibition of BDCA2-positive B cells and normalization of proinflammatory monocyte-derived macrophages via the global suppression of type I IFN
Single-cell RNA-seq · human · 16 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 2 × R1_CpG-A+230V vs 2 × R2_D1_CpG-A+230V vs 2 × R2_D2_CpG-A+230V vs 2 × R2_D3_CpG-A+230VGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE314089_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1390069 and SRA study SRP655959. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9381396 R1_Ctrl
- GSM9381397 R1_CpG-A
- GSM9381398 R1_CpG-A+230V3 R1_CpG-A+230V
- GSM9381399 R1_CpG-A+230V5 R1_CpG-A+230V
- GSM9381400 R2_D1_Ctrl
- GSM9381401 R2_D1_CpG-A
- GSM9381402 R2_D1_CpG-A+230V3 R2_D1_CpG-A+230V
- GSM9381403 R2_D1_CpG-A+230V5 R2_D1_CpG-A+230V
- GSM9381404 R2_D2_Ctrl
- GSM9381405 R2_D2_CpG-A
- GSM9381406 R2_D2_CpG-A+230V3 R2_D2_CpG-A+230V
- GSM9381407 R2_D2_CpG-A+230V5 R2_D2_CpG-A+230V
- GSM9381408 R2_D3_Ctrl
- GSM9381409 R2_D3_CpG-A
- GSM9381410 R2_D3_CpG-A+230V3 R2_D3_CpG-A+230V
- GSM9381411 R2_D3_CpG-A+230V5 R2_D3_CpG-A+230V
- GSE272019 Opposing Regulation of TNF Responses and IL-1b+ Macrophages by PGE2-cAMP Signaling and IFN-g [RNA-seq] 48 samples shares ifn, macrophages
- GSE294918 IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself [RNA-Seq] 20 samples shares ifn, macrophages
- GSE298341 ISG15-Mediated Suppression of Type I Interferon Signaling Leads to Susceptibility to Epstein-Barr Virus Infection (LCL_IFN_treatment_BulkRNAseq) 18 samples shares ifn, suppression
- GSE277050 Loss of ARID1A leads to a cold tumor phenotype via suppression of IFNγ signaling 12 samples shares ifn, suppression
- GSE294916 IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself [CUT&Tag] 28 samples shares ifn, macrophages
- GSE272017 Opposing Regulation of TNF Responses and IL-1b+ Macrophages by PGE2-cAMP Signaling and IFN-g [ATAC-seq] 24 samples shares ifn, macrophages
- GSE294915 IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself [ATAC-Seq] 22 samples shares ifn, macrophages
- GSE244130 Epigenomic Landscapes Define Differential JAK Inhibitor Sensitivity in IFN-γ-Primed Human Macrophages 16 samples shares ifn, macrophages
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.