GEO series

Inflammatory Monocytes Constrain YAP-Induced Cell Proliferation [bulk RNA-seq]

GSE314321 Mus musculus (mouse) RNA-seq (gene expression) 15 samples Submitted 2026/07/01 Platform GPL24247

At a glance

RNA-seq (gene expression) · mouse · 15 samples

What it is: RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism: Mus musculus (mouse)
Samples: 15 samples: 6 × bulk RNA-seq LATS KO vs 5 × bulk RNA-seq Yap OE vs 4 × bulk RNA-seq TdTomatoGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper: Inflammatory monocytes constrain YAP-induced cell proliferationScience advances · 2026

Summary (written by the submitters)

YAP and its paralog, TAZ are transcriptional co-activators of the Hippo pathway that regulate cell growth. Their structural distinctiveness suggests important independent functional differences. To investigate this further, we generated YAP- and TAZ-predominant clones in the liver and followed their long-term behavior. YAP clones rapidly de-differentiate cells into a stem cell-like state with inflammatory immune cell recruitment followed by their clearance.

Read the full summary ↓

In contrast, TAZ clones promote an anti-inflammatory immune environment resulting in their long-term maintenance, massive organ growth and increased mortality. YAP clones recruit inflammatory blood-derived monocytes, which if inhibited permits YAP clonal growth. Consistent with these results, YAPHigh colorectal cancer (CRC) patients had a 67% 5-year survival rate, while TAZHigh CRC patients did not survive to 5 years. Similar trends were seen in hepatocellular carcinoma patients. These findings underscore the importance of understanding the intrinsic differences in YAP and TAZ biology as independent drivers of disease.

Published in

Inflammatory monocytes constrain YAP-induced cell proliferation

Singh S, Tahmasian N, Liu JJ et al. · Science advances 2026 · PMID 42341114 · doi:10.1126/sciadv.aee8580

This dataset

Open GSE314321 in finder → Find more mouse RNA-seq datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE314321_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1390993 and SRA study SRP656826. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42341114) ↗

Study design

6 × bulk RNA-seq LATS KO vs 5 × bulk RNA-seq Yap OE vs 4 × bulk RNA-seq TdTomato

Supports a between-group comparison across 15 samples.

How we read this: 3 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM9393567 bulk RNA-seq TdTomato 1 bulk RNA-seq TdTomato
GSM9393568 bulk RNA-seq TdTomato 2 bulk RNA-seq TdTomato
GSM9393569 bulk RNA-seq TdTomato 3 bulk RNA-seq TdTomato
GSM9393570 bulk RNA-seq TdTomato 4 bulk RNA-seq TdTomato
GSM9393571 bulk RNA-seq LATS KO 1 bulk RNA-seq LATS KO
GSM9393572 bulk RNA-seq LATS KO 2 bulk RNA-seq LATS KO
GSM9393573 bulk RNA-seq LATS KO 3 bulk RNA-seq LATS KO
GSM9393574 bulk RNA-seq LATS KO 4 bulk RNA-seq LATS KO
GSM9393575 bulk RNA-seq LATS KO 5 bulk RNA-seq LATS KO
GSM9393576 bulk RNA-seq LATS KO 6 bulk RNA-seq LATS KO
GSM9393577 bulk RNA-seq Yap OE 1 bulk RNA-seq Yap OE
GSM9393578 bulk RNA-seq Yap OE 2 bulk RNA-seq Yap OE
GSM9393579 bulk RNA-seq Yap OE 3 bulk RNA-seq Yap OE
GSM9393580 bulk RNA-seq Yap OE 4 bulk RNA-seq Yap OE
GSM9393581 bulk RNA-seq Yap OE 5 bulk RNA-seq Yap OE

Datasets on a similar topic

GSE314318 Inflammatory Monocytes Constrain YAP-Induced Cell Proliferation [snRNA-seq] 8 samples shares proliferation, yap-induced, monocytes, constrain, rna-seq
GSE275712 A novel noninvasive murine model of neonatal hypoxic ischemic encephalopathy demonstrates developmental delay and motor deficits with activation of inflammatory pathways in monocytes [bulkRNA-seq] 22 samples shares monocytes, rna-seq, bulk
GSE228456 Cell-intrinsic effect of IL-7R signaling of monocytes within C57BL/6J mouse ears infected with Leishmania major [bulk RNA-seq] 87 samples shares monocytes, rna-seq, bulk
GSE263738 Bi-directional immunosuppressive interactions between astrocytes and glioblastoma cells identified by barcoded viral tracing [Mouse Bulk RNA-Seq Dataset of Monocytes, T Cells and Astrocytes 63FG] 57 samples shares monocytes, rna-seq, bulk
GSE263737 Bi-directional immunosuppressive interactions between astrocytes and glioblastoma cells identified by barcoded viral tracing [Mouse Bulk RNA-Seq Dataset of Monocytes, T Cells and Astrocytes 5OLJ] 33 samples shares monocytes, rna-seq, bulk
GSE293599 The Polycomb Protein EED Constrains the SCLC Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation [Bulk RNA-seq] 50 samples shares constrain, rna-seq, bulk
GSE306514 Chemokine receptor expression patterns delineate distinct interstitial macrophage subsets in the lung and define a trajectory from monocytes to mature macrophages, bulk RNA-sequencing data 24 samples shares monocytes, rna-seq, bulk
GSE274183 A novel noninvasive murine model of neonatal hypoxic ischemic encephalopathy demonstrates developmental delay and motor deficits with activation of inflammatory pathways in monocytes [scRNA-seq] 24 samples shares monocytes, rna-seq

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.