The human Flower isoform hFWE4 facilitates cornification in cutaneous squamous cell carcinoma
RNA-seq (gene expression) · human · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Cutaneous squamous cell carcinomaThis series is part of our curated briefing on it.
- Samples
- 23 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The human Flower isoform hFWE4 facilitates cornification in cutaneous squamous cell carcinomaJID innovations : skin science from molecules to population health · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE314399_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1390829 and SRA study SRP656530. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 23 samples.
How we read this: 6 replicated groups read from 23 sample titles; they account for 23 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9395681 WT, 5B2, 5526 WT, 5B2,
- GSM9395682 WT, 5B2, 5527 WT, 5B2,
- GSM9395683 WT, 5B2, 5528 WT, 5B2,
- GSM9395684 WT, 5B2, 5529 WT, 5B2,
- GSM9395685 WT, 6C9, 5530 WT, 6C9,
- GSM9395686 WT, 6C9, 5531 WT, 6C9,
- GSM9395687 WT, 6C9, 5532 WT, 6C9,
- GSM9395688 WT, 6C9, 5533 WT, 6C9,
- GSM9395689 WT, 6C10, 5534 WT, 6C10,
- GSM9395690 WT, 6C10, 5535 WT, 6C10,
- GSM9395691 WT, 6C10, 5536 WT, 6C10,
- GSM9395692 WT, 6C10, 5537 WT, 6C10,
- GSM9395693 KO, 2F7, 5538 KO, 2F7,
- GSM9395694 KO, 2F7, 5539 KO, 2F7,
- GSM9395695 KO, 2F7, 5540 KO, 2F7,
- GSM9395696 KO, 2B8, 5542 KO, 2B8,
- GSM9395697 KO, 2B8, 5543 KO, 2B8,
- GSM9395698 KO, 2B8, 5544 KO, 2B8,
- GSM9395699 KO, 2B8, 5545 KO, 2B8,
- GSM9395700 KO, 1G10, 5546 KO, 1G10,
- GSM9395701 KO, 1G10, 5547 KO, 1G10,
- GSM9395702 KO, 1G10, 5548 KO, 1G10,
- GSM9395703 KO, 1G10, 5549 KO, 1G10,
- GSE284467 Multi-omic Sequencing of Intermediate to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes 75 samples same disease briefing · shares cutaneous, squamous
- GSE319969 Spatial and Bulk Transcriptomic Profiling Defines the Molecular Evolution of Cutaneous Squamous Cell Carcinoma and Reveals Stage-Specific Biomarkers of Clinical Relevance [RNA-Seq] 24 samples same disease briefing · shares cutaneous, squamous
- GSE326341 Characterization of a Human Cutaneous Squamous Cell Carcinoma Xenograft Mouse Model 20 samples same disease briefing · shares cutaneous, squamous
- GSE260920 Loss of DUSP1 expression creates a cold tumor microenvironment in cutaneous squamous cell carcinoma 17 samples same disease briefing · shares cutaneous, squamous
- GSE200334 Single cell transcriptomes of genetic landscape from actinic keratosis to cutaneous squamous cell carcinoma 14 samples same disease briefing · shares cutaneous, squamous
- GSE252347 RNA-Seq of human cutaneous squamous cell carcinoma cell lines and normal human epidermal keratinocytes. 12 samples same disease briefing · shares cutaneous, squamous
- GSE341811 Pleckstrin-2 Promotes Cutaneous Squamous Cell Carcinoma by Recruiting Profilin-1 to the Membrane to Destabilize Cytosolic PTEN 6 samples same disease briefing · shares cutaneous, squamous
- GSE262947 Single cell transcriptomics reveals dysregulated immnue homeostasis in different stages in HPV-induced cutaneous squamous cell carcinoma 4 samples same disease briefing · shares cutaneous, squamous
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.