GEO series
Characterization of a Human Cutaneous Squamous Cell Carcinoma Xenograft Mouse Model
GSE326341
Homo sapiens
Expression profiling by high throughput sequencing
20 samples
2026/06/05
GPL24676
Summary
To study the biology of immune cell biology (e.g. human cutaneous gamma delta T cell) in human skin tumours, an in vivo SCC xenograft mouse model was established. To closely resemble the human skin microenvironment, human tumour cells were introduced into an engineered human skin on the back of NSG mice. Transcriptome analysis of bulk-RNAseq data generated from biopsies of the xenograft model as well as human skin and tumour was conducted to test which features of the model resemble the situation in humans.
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Paper (PMID 42341104) ↗
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