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Species-specific splicing differences are primarily governed by changes in cis-acting sequences

GSE31454 Homo sapiens; Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2012/12/01 Platform GPL9052Platform GPL9185
Summary
We assessed whether human transcripts expressed in an aneuploid mouse that carries human chromosome 21 (HsChr21) are spliced in a human-specific or mouse-specific fashion. In almost all cases, human-specific alternative splicing is maintained in the mouse nucleus. Species-specific splicing therefore appears to be primarily directed by cis-acting elements, rather than changes in the levels or activities of trans-acting factors.
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Also filed as BioProject PRJNA145829 and SRA study SRP007862. Searching any of these in the dataset finder brings you back here.

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