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Transcription co-repressors Panky and Panky-like are essential for retinal cone photoreceptor integrity and survival by modulating ganglioside metabolism

GSE314562 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/06 Platform GPL24247
Summary
To investigate the in vivo functions of mouse Panky and its paralog, Panky-like (Ankrd33b), we generated and analyzed the Panky/Panky-like double knockout (PPL DKO) mice. PPL DKO mice exhibited decreased light-evoked activities, impaired morphology of cone photoreceptors, and disrupted membrane integrity in the cone outer segments and synaptic terminals, followed by cone death at a later stage. RNA-seq analysis revealed that Cerkl gene, whose mutations in human ortholog CERKL cause retinitis pigmentosa (RP26), was upregulated in Panky/Panky-like/Nrl triple KO mouse retinas, in which loss of Nrl converts rods into cones. Our findings suggest that the regulation of Cerkl expression in cone photoreceptors by Panky and Panky-like is essential for cone photoreceptor integrity and survival.
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Also filed as BioProject PRJNA1391506 and SRA study SRP656819. Searching any of these in the dataset finder brings you back here.

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