GEO series
Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis
GSE314582
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2026/04/03
GPL19057GPL24247
Summary
TLR5 is a pathogen recognition receptor against flagellin that is expressed in various epithelial and immune cells. Mice pretreated with TLR5-agonist are protected against bleomycin-induced pulmonary fibrosis. However, the mechanisms by which TLR5-agonism protects against pulmonary fibrosis remains to be determined. Here, we found innate host defense gene sets to be selectively elevated in sorted type 2 alveolar epithelial.
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Paper (PMID 42234773) ↗
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