Targeting cathepsin B alleviates activation of IL-17A-netrophils axis to suppress atopic dermatitis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × Blank vs 4 × Model vs 4 × IsoLGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE314668_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1392434 and SRA study SRP657243. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9408941 Blank-1 Blank
- GSM9408942 Blank-2 Blank
- GSM9408943 Blank-3 Blank
- GSM9408944 Blank-4 Blank
- GSM9408945 Model-1 Model
- GSM9408946 Model-2 Model
- GSM9408947 Model-3 Model
- GSM9408948 Model-4 Model
- GSM9408949 IsoL-1 IsoL
- GSM9408950 IsoL-2 IsoL
- GSM9408951 IsoL-3 IsoL
- GSM9408952 IsoL-4 IsoL
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares activation, targeting, suppress
- GSE293315 MRPGRX2 Antagonist Treatment Prevents Inflammation and Disease in a Mouse Model of Atopic Dermatitis Dataset 2 35 samples shares dermatitis, atopic
- GSE319612 Rothia mucilaginosa Alleviates Constipation through Gut Microbiota Remodeling and Neuroactive Pathway Activation 26 samples shares alleviates, activation
- GSE319401 Exercise Mitigates Cardiac Dysfunction Post-MI in Ovariectomized Mice via miR-21/Sox7-Mediated Suppression of Cardiac Fibroblast Activation 24 samples shares activation, suppress
- GSE303657 R-spondin 2 suppresses hepatic steatosis via activation of AMPK-ACC signaling 12 samples shares activation, suppress
- GSE307681 Dermal fibroblasts respond to interleukin-4 and 13 and promote T-cell recruitment in atopic dermatitis 12 samples shares dermatitis, atopic
- GSE190309 Single nuclei RNA and ATAC sequencing of mouse trigeminal ganglia at baseline and in atopic dermatitis-like disease. 14 samples shares dermatitis, atopic
- GSE255212 Transcriptomic Signatures of WNT-Driven Pathways and Granulosa Cell-Oocyte Interaction during Primordial Follicle Activation 762 samples shares activation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.