Inhibiting Aberrant Interfacial Friction Regulates Cell Fate and Promotes Cartilage Regeneration
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 4 × A vs 4 × B vs 4 × CGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE314689_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1392458 and SRA study SRP657255. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9409378 A1 A
- GSM9409379 A2 A
- GSM9409380 A3 A
- GSM9409381 A4 A
- GSM9409382 B1 B
- GSM9409383 B2 B
- GSM9409384 B3 B
- GSM9409385 B4 B
- GSM9409386 C1 C
- GSM9409387 C2 C
- GSM9409388 C3 C
- GSM9409389 C4 C
- GSE278641 Growth signaling promotes H2A.Z deposition by SRCAP to sustain somatic tissue regeneration [RNA-Seq] 42 samples shares regeneration, promotes
- GSE271815 A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration 22 samples shares regeneration, cartilage
- GSE249229 A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration [bulk RNA-seq] 18 samples shares regeneration, cartilage
- GSE296344 Cold exposure promotes the progression of osteoarthritis through downregulating APOE in cartilage 12 samples shares cartilage, promotes
- GSE295278 Hyperbaric Oxygen Promotes Both the Proliferation and Chemosensitization of Glioblastoma Cells by Inhibiting HIF1α/HIF2α-ABCG2 12 samples shares inhibiting, promotes
- GSE291573 Glucosidase Alpha Neutral C Promotes Influenza Virus Replication by Inhibiting Proteosome-Dependent Degradation of Hemagglutinin 12 samples shares inhibiting, promotes
- GSE248169 PiR-hsa-4447944 serves as an oncogenic mediator in prostate cancer and promotes the development of castration resistance by inhibiting NEFH expression 12 samples shares inhibiting, promotes
- GSE294455 Sphingolipids in extracellular vesicles released from the skeletal muscle plasma membrane control muscle stem cell fate during muscle regeneration 10 samples shares regeneration, fate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.