Vincristine induces spermatogenic impairment in a B-ALL PDX mouse model via downregulation of Tssk4 and Ccdc159: RNA-seq transcriptomic profiling
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Vincristine induces sperm malformation and motility dysfunction in mice by downregulating Tssk4 and Ccdc159Reproductive toxicology (Elmsford, N.Y.) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE314794_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1392611 and SRA study SRP657455. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 20 more — browse all 20 samples with per-sample file links →
- GSE283254 AS1842856: A dual FOXO1-GSK3 inhibitor for targeting B-ALL-specific molecular vulnerabilities 24 samples shares b-all
- GSE266166 B-ALL GPR65 expression influences susceptibility to CAR-T therapy through a VEGF and macrophage-dependent mechanism 22 samples shares b-all
- GSE280505 Leukaemia cell intrinsic and extrinsic factors cooperate to facilitate the survival and proliferation of KMT2A-rearranged B-ALL in the CNS niche. 16 samples shares b-all
- GSE308937 Pex5 WT vs Pdx1-cre KO Islet RNA (WT are a combination of Pex5 floxed and non floxed Cre only) 15 samples shares pdx
- GSE245287 Beta-catenin deletion and GSK3b inhibition in B-ALL cells 12 samples shares b-all
- GSE278790 PDX1 Phosphorylation Mediates Amino Acid-mTORC1 Signaling in Pancreatic β-Cells [RNA-seq] 12 samples shares pdx
- GSE196767 Gene expression changes in B-ALL upon oncogenic β-catenin activation [RNA-Seq] 12 samples shares b-all
- GSE303047 MODY PDX1P33T: A Mouse Model Reveals Phenotypic Divergence from Human Disease 11 samples shares pdx
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.