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Xenopus gene ag1 influence on the skin would healing in mice

GSE315128 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/11 Platform GPL18480
Summary
Here, we investigated whether the ag1 gene, which plays a key role in regeneration in fish and amphibians and was lost in amniotes, could enhance skin wound healing in mice. We generated transgenic mice with inducible expression of the Xenopus laevis ag1 gene in the skin and compared wound healing dynamics between induced and non-induced groups. Induction of ag1 resulted in approximately 20% faster wound closure. Transcriptomic analysis revealed enhanced activation of multpathways involved in wound repair
Published in
Restoring Ag1, an ancient regeneration gene lost in amniotes, accelerates skin healing in mice
Kosykh AV, Zhigmitova EB, Evtushenko NA et al. · Frontiers in cell and developmental biology 2026 · PMID 41799438 · doi:10.3389/fcell.2026.1706902
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Also filed as BioProject PRJNA1395028 and SRA study SRP658584. Searching any of these in the dataset finder brings you back here.

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