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Single-cell RNA-seq analysis of immune microenvironment changes in pancreatic cancer following combined EZH2 and KRAS inhibition

GSE315131 Mus musculus Expression profiling by high throughput sequencing 3 samples Submitted 2026/01/31 Platform GPL24247
Summary
Our study demonstrated that combined treatment with the EZH2 inhibitor tazemetostat and the KRAS inhibitor RMC-6236 significantly suppressed the growth of both subcutaneous and orthotopic tumors. To investigate changes in the tumor microenvironment following combined EZH2 and KRAS inhibition in pancreatic cancer, mice bearing subcutaneous KPC tumors were treated with vehicle, RMC-6236 alone, or RMC-6236 in combination with tazemetostat. CD45⁺ cells were isolated and subjected to 10× Genomics single-cell RNA sequencing.
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Also filed as BioProject PRJNA1395042 and SRA study SRP658598. Searching any of these in the dataset finder brings you back here.

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