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RNA-seq technique to identify key differentially expressed genes in hepatocytes of HFD-treated Lyve1-Cre;Heg1fl/fl mice.

GSE315356 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/06/18 Platform GPL24247
Summary
Heart-of-glass (Heg) is a type I transmembrane protein. Previous studies have demonstrated that knockout of the Heg1 gene in mouse liver endothelial cells disrupts hepatic metabolic zonation by downregulating Wnt ligands in endothelial cells. To further investigate the metabolic changes in hepatocytes, alterations in Wnt receptor genes, and other potential genetic changes following endothelial-specific Heg1 knockout in mice with hepatic steatosis, this study was conducted.
Published in
Liver Endothelial Heg1 Signal Limits Hepatic Steatosis via Wnt-Mediated Fatty Acid Oxidation in Hepatocytes
Rao X, Zhao Q, Chen J et al. · Cellular and molecular gastroenterology and hepatology 2026 · PMID 42119921 · doi:10.1016/j.jcmgh.2026.101807
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Direct links to NCBI, no account and no request form: the whole study as GSE315356_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1396585 and SRA study SRP659129. Searching any of these in the dataset finder brings you back here.

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