Mice with targeted deletion of the Vasoactive Intestinal Peptide (VIP) gene have spontaneous pulmonary arterial hypertension exaggerated with hypoxia
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 6 × WT Normoxia vs 5 × VIPKO Hypoxia vs 4 × WT Hypoxia vs 4 × VIPKO NormoxiaGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE315475_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1397210 and SRA study SRP659397. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9429250 WT Hypoxia 1 WT Hypoxia
- GSM9429251 WT Hypoxa 2
- GSM9429252 WT Hypoxia 3 WT Hypoxia
- GSM9429253 WT Hypoxia 4 WT Hypoxia
- GSM9429254 WT Hypoxia 5 WT Hypoxia
- GSM9429255 WT Normoxia 1 WT Normoxia
- GSM9429256 WT Normoxia 2 WT Normoxia
- GSM9429257 WT Normoxia 3 WT Normoxia
- GSM9429258 WT Normoxia 4 WT Normoxia
- GSM9429259 WT Normoxia 5 WT Normoxia
- GSM9429260 WT Normoxia 6 WT Normoxia
- GSM9429261 VIPKO Normoxia1 VIPKO Normoxia
- GSM9429262 VIPKO Normoxia2 VIPKO Normoxia
- GSM9429263 VIPKO Normoxia3 VIPKO Normoxia
- GSM9429264 VIPKO Normoxia4 VIPKO Normoxia
- GSM9429265 VIPKO Hypoxia 1 VIPKO Hypoxia
- GSM9429266 VIPKO Hypoxia 2 VIPKO Hypoxia
- GSM9429267 VIPKO Hypoxia 3 VIPKO Hypoxia
- GSM9429268 VIPKO Hypoxia 4 VIPKO Hypoxia
- GSM9429269 VIPKO Hypoxia 5 VIPKO Hypoxia
- GSE261001 Transcriptional effects of VIP on murine intestinal stem cells 37 samples shares vip, intestinal
- GSE316502 Transcriptomic Profiling of the Sex-linked Biological Pathways of Severe Pulmonary Arterial Hypertension associated with Endothelial Cell Caveolin-1 Depletion and Chronic Hypoxia 35 samples shares hypertension, pulmonary
- GSE283766 Saliva alleviates hypertension through enrichment of intestinal Bacteroides thetaiotaomicron 14 samples shares hypertension, intestinal
- GSE289897 Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension 12 samples shares hypertension, pulmonary
- GSE301479 RNA-seq analysis of pulmonary arterial smooth muscle cells (PASMCs) and bronchial smooth muscle cells (BSMCs) after pulmonary arterial hypertension (PAH) treatment 12 samples shares hypertension, pulmonary
- GSE317568 Integrin β3 Deficiency Unleashes Spontaneous Pulmonary Inflammation by Promoting B Cell Hyperactivation via the CD40-CD40L Axis 12 samples shares spontaneous, pulmonary
- GSE272157 RNA sequencing of lung tissue from wildtype and hypoxia-induced pulmonary hypertension/hypoxia-induced pulmonary hypertension mice under aerobic exercise conditions 10 samples shares hypertension, pulmonary
- GSE316584 MicroRNA-224 Orchestrates the BMP Pathway and Represents a New Therapeutic Target for Pulmonary Arterial Hypertension 9 samples shares hypertension, pulmonary
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.