← BioTransfer GEO Dataset Finder
GEO series

Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification

GSE315481 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/01/07 Platform GPL18573
Summary
Acquired chromosomal DNA copy gains are a feature of many tumors; however, the mechanisms that underpin oncogene amplifi cation are poorly understood. Recent studies have begun to uncover the importance of epigenetic states and histone lysine methyltrans_x0002_ferases (KMT) and demethylases (KDM) in regulating transient site-specifi c DNA copy-number gains (TSSG). In this study, we reveal a critical interplay between a myriad of lysine methyltransferases and demethylases in modulating H3K4/9/27 methylation balance to control extrachromosomal amplifi ca_x0002_tion of the EGFR oncogene. This study further establishes that cellular signals (hypoxia and EGF) are able to directly promote EGFR amplifi cation through modulation of the enzymes controlling EGFR copy gains. Moreover, we demonstrate that chemical inhibitors targeting specifi c KMTs and KDMs are able to promote or block extrachromosomal EGFR amplifi cation, which identifi es potential therapeu
Published in
Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification
Clarke TL, Tang R, Chakraborty D et al. · Cancer discovery 2020 · PMID 31776131 · doi:10.1158/2159-8290.CD-19-0463
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE315481_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1397222 and SRA study SRP659409. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all human ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.