T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis [ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasisThe Journal of clinical investigation · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE316006_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1400328 and SRA study SRP660951. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9442923 3384796_WT_rTreg_NO1
- GSM9442924 3384797_WT_rTreg_NO2
- GSM9442925 3384798_WT_rTreg_NO3
- GSM9442926 3384799_WT_rTreg_TCR1
- GSM9442927 3384800_WT_rTreg_TCR2
- GSM9442928 3384801_WT_rTreg_TCR3
- GSM9442929 3384802_KDM6B_rTreg_NO1
- GSM9442930 3384803_KDM6B_rTreg_NO2
- GSM9442931 3384804_KDM6B_rTreg_NO3
- GSM9442932 3384805_KDM6B_rTreg_TCR1
- GSM9442933 3384806_KDM6B_rTreg_TCR2
- GSM9442934 3384807_KDM6B_rTreg_TCR3
- GSE291449 T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis 46 samples shares kdm6b, demethylase, homeostasis, receptor, maintain, induces, lysine
- GSE267447 Loss of Nuclear Receptor Nr4a3 Alleviates Cellular Senescence to Promote Adult Direct Cardiac Reprogramming (ATAC-Seq) 16 samples shares receptor, atac-seq
- GSE240787 DNMT3b mediates TGFβ-Smad2/3 action to maintain Epiblast homeostasis upon Smad4 Loss 34 samples shares homeostasis, maintain
- GSE240578 MAD2-dependent insulin receptor endocytosis regulates metabolic homeostasis 20 samples shares homeostasis, receptor
- GSE309618 Mesangial cell-derived extracellular matrix protein 1 is essential for maintaining mesangial matrix homeostasis and glomerular architecture 18 samples shares homeostasis, maintain
- GSE276730 The histone lysine demethylase KDM7A contributes to reward memory via Fscn1-induced synaptic plasticity in the medial prefrontal cortex 16 samples shares demethylase, lysine
- GSE314547 Estradiol disrupts constitutive androstane receptor (CAR)-mediated bile acid homeostasis in a murine model of intrahepatic cholestasis of pregnancy (ICP), and this effect is reversed by CAR ligands 16 samples shares homeostasis, receptor
- GSE186134 B1b cell homeostasis is maintained by CD40 in atherosclerosis 16 samples shares homeostasis, maintain
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.