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Maternal antibodies orchestrate the establishment of salivary and oral mucosal immunity_Gingiva

GSE316211 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/23 Platform GPL24247
Summary
The establishment of mucosal homeostasis after birth involves mutual development of the microbiota and the immune system, with each mucosal barrier has specific mechanisms. Here, we show that in utero-delivered maternal IgG antibodies are translocated to the salivary glands and secreted to the neonatal saliva. As a result, the microbial burden of the neonate oral cavity and salivary glands is reduced. In the absence of maternal antibodies, oral dendritic cells migrate in higher frequencies to the salivary glands resulting in elevated activation of T and B cells, while dampening T regulatory cells. The IgG/IgA balance in the adult saliva was also dysregulated. The absence of maternal antibodies further regulates the adult gingival immunity, a key oral barrier, increasing alveolar bone loss during experimental periodontitis. This work reveals the importance of the salivary-oral axis during neonatal life via maternal antibodies, orchestrating local mucosal immunity and protecting against pathological damage in adulthood.
Published in
Maternal antibodies regulate the establishment of murine oral and salivary mucosal immunity
Naamneh R, Attar Y, Netanely-Rimon Y et al. · Nature communications 2026 · PMID 41957019 · doi:10.1038/s41467-026-71704-5
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Also filed as BioProject PRJNA1401802 and SRA study SRP661569. Searching any of these in the dataset finder brings you back here.

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